Us5543158a us08096,370 us9637093a us5543158a us 5543158 a us5543158 a us 5543158a us 9637093 a us9637093 a us 9637093a us 5543158 a us5543158 a us 5543158a authority us united states prior art keywords poly nanoparticle microparticle alkylene glycol surface prior art date 19930723 legal status the legal status is an assumption and is not a legal conclusion. Biodegradable polyorthoester rods after left 9 and right 16 weeks of implantation in rabbits. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal. Pharmaceutics free fulltext mathematical modeling of. Reaction is carried out in a glass flask facility to.
Although significant advances have been made in its treatment, there are several challenges associated with traditional methods, for example, limited donor skin tissue for transplantation and inflammation during longterm healing time. Physically targeted intravenous polyurethane nanoparticles for. Introduction to nanoparticle characterization with afm 1 revision. Pharmaceutics free fulltext ophthalmic drug delivery. Drug delivery nanoparticles formulation and mafiadoc. Polyortho estersfrom concept to reality biomacromolecules. Synthesis of highly charged, monodisperse polystyrene colloidal particles for the fabrication of photonic crystals chad e. Poe polyorthoester pva polyvinyl alcohol sem scanning electron microscopy t g glass transition temperature tga thermogravimetric analysis. Free download nanoparticles seminar ppt and pdf report. Some of them are carbonbased nanoparticles, ceramic nanoparticles, metal nanoparticles, semiconductor nanoparticles, polymeric nanoparticles and lipidbased nanoparticles. Article pdf available in international journal of nanoparticles 54. Synthesis of nanoparticles physical,chemical and biological.
Asher1 department of chemistry, university of pittsburgh, pittsburgh, pennsylvania 15260 received april 10, 2000. Despite huge diversity of formulations, diffusion phenomena are involved in practically all. A nanoparticle is considered to a group of atoms which are bonded together and possess a structural radius of less than 100 nm. Introduction to nanoparticle characterization with afm. Nanoparticles have contributed to many of these advances. Nanoparticle reinforced polymers have gained a lot of attention lately due to the unusual viscoelastic behavior of these systems. Titania nanoparticles synthesized by solgel technique.
Preparation of micronsize monodisperse polymer particles by seeded polymerization utilizing the dynamic monomer swelling method. Different controlled drug delivery system presented by sudhir karna m. Encapsulation efficiency ranged between 21 and 63%, depending on the type of the watersoluble molecule used. Interactions between polymers and nanoparticles arxiv. Polyanhydrides were first investigated in detail by hill and carothers 168 and were considered in the 1950s for possible applications as textile fibers 169. Nanoparticle any particle of a substance with dimensions in the region of onetenth of a micron. Cardiovascular disease accounts for a significant percentage of mortality and morbidity in the ageing population and has an estimated increase in the coming years. Biodegradable polymers for microencapsulation of drugs. Uv621 cmvisible analysis shows the occurrence of strong red shift, confirming the presence of nanoparticles which is essential for higher photo catalytic activities. Surfaceeroding polyortho ester amides for highly efficient oral. A applications for nanoparticles while nanoparticles are important in a diverse set of fields, they can generally be classified as one of two types. Nanoparticles nanoparticles are the simplest form of structures with sizes in the nm range.
The yttrium hydroxyacetate particles were chosen primarily as a model system for inorganic colloids, and also because of potential applications in the fields of. Characterization of nanoparticles by scanning electron microscopy in transmission mode. A medlineindexed journal publishing research in the design, development, manufacture, and evaluation of traditional and novel drug delivery systems, emphasizing practical solutions and applications to theoretical and researchbased problems. Antibioticcoated nanoparticles northwestern university. Polyorthoester type iv avoids the addition of acidic excipients required in polyorthoester type ii, which often diffuse uncontrolled out of the polymer matrix and thus lead to erratic degradation kinetics. To address these challenges, in this study we present a method to fabricate poly. Critical evaluation of biodegradable polymers used in nanodrugs. Metallic nanoparticles can be synthesized through many methods. To avoid contamination, the nanoparticles were produced by precipitation by mixing acetone solution with water. Polyllactide acid plla, polyorthoester poe, and poly llactidecoglycolide plga 12, can be selected for fabricating. Analysis of polyorthoester rods after 9 and 16 weeks of implantation in rabbits shows significant surface degradation, but the core of the drug delivery system remains intact see figure 10. Topical eye drops are the most commonly used formulation in ocular drug delivery.
Tga analysis reveals that the synthesized titania nanoparticles were. Embedding of active substances in supramolecular systems has as the main goal to ensure the controlled release of the active ingredients. Longchain polyorthoesters as degradable polyethylene. From the afm pictures we can see that the size of nanoparticles is slightly increased, after 24 hours.
Design and fabrication of metalpolymer based coreshell artificial nanodielectrics for capacitor applications a thesis presented to the faculty of the department of electrical and computer engineering. Silver nanoparticles nps have been the subjects of researchers because of their unique properties e. Biosynthesis of silver nanoparticles from orange peel. Nanoparticles exist in the natural world and are also created as a result of human activities. These advantages would lead to less frequency in dressing replacement. Preparation, characterization and stabilization of nano. Whatever the final architecture or entrapment mechanism, modeling of release is challenging due to the moving boundary conditions and complex initial conditions. Polyortho ester urethanes poeus copolymers were synthesized via.
The complement system consists of a number of small proteins found in the blood, and normally circulating as. Cadmium acetate is added to a desired medium like water, ethanol, propanol etc. There is an urgent clinical need for improved cardiovascular devices, which mainly include vascular bypass grafts, vascular stents, and heart valves, which will promote desirable bloodbiomaterial interactions. However, when trisodium citrate was used, the particle size was controlled up to 4 weeks, which is also. The persistence of commodity polymers makes the research for degradable alternatives with similar properties necessary.
Pdf syntheses of sugar polyorthoesters through reverse. Roth department of physics, oakland university, rochester, michigan abstract innovations and discoveries are constantly being made in the medical field. Dna can bind to the surface of growing nanoparticles. Our previous studies demonstrated that polyortho ester poe nanoparticles were biodegradablebiocompatible and were capable of longterm sustained release. T kalaichelvan 1 1centre for advanced studies in botany, university of madras, chennai 600 025, india 2 kongu arts and science college, erode 638 001. In principle any collection of atoms bonded together with a structural radius of nanoparticle. Chemically, nanoparticles have large surfacetovolume ratio. Plga nanoparticles less than 150 nm diameter were produced. Polyorthoester type ivtypes are also accessible under the very mild conditions of interfacial polycondensation. E buhr 1, n senftleben 2, t klein 1, d bergmann 1, d gnieser 1, c g frase 1 and h bosse 1. Nanoparticle size and surface properties determine the. Synthesis of highly phresponsive glucose polyorthoester.
Department of pharmaceutics invertis institute of pharmacy invertis university bareilly presented to mr. Polyortho ester nanoparticlebased targeted intraocular. Nanoparticles are the easiest form of structures which have the sizes in the range of nanometer. On the other hand, there are some general properties of the nanoparticles. This research has focused on studying development of the nanocomposite materials performance with water tree growth resistance superior to the. Provided herein are antibiotic coated nanoparticles and methods of treating bacterial infection therewith. Intestinepenetrating, phsensitive and doublelayered. Synthesis of highly phresponsive glucose polyorthoester article in angewandte chemie international edition 5251 december 20 with 54 reads how we measure reads. Published 30 june 2009 2009 iop publishing ltd measurement science and technology, volume 20, number 8.
In polymer nanoparticle composites, even very weak interactions between the particles and the polymer repeat. Nanoparticle, ultrafine unit with dimensions measured in nanometers. The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Polyortho ester nanoparticles targeted for chronic intraocular. Their low hydrolytic stability, the major limitation for their industrial applications, was later recognized as a potential advantage by langer et al. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.
Synthesis of highly charged, monodisperse polystyrene. The present invention provides microfluidic systems and methods for the production of particles e. In our previous work, a series of nanoparticles based on polyortho ester poe were explored for intravenous drug delivery, which were stable in blood circulation. Six different polystyrene nanoparticles were studied. Pdf polymeric micro and nanoparticles as promising drug delivery. Present status of nanoparticle research for treatment of.
There are many kinds of nanoparticles so it would be very difficult to provide a unifying answer. Nanoparticles can be classified into different types according to the size, morphology, physical and chemical properties. The surface of the plga particles was modified by adsorption of watersoluble plapeg block copolymer or poloxamine 908 forming an adsorbed layer thickness 10 nm. For example, the release of tetracycline from a polyorthoester matrix was. Characterization of nanoparticles by scanning electron. Nps are tiny materials having size ranges from 1 to 100 nm. Ringopening metathesis copolymerization romp of 1,5cyclooctadiene with four different cyclic orthoester monomers gave linear copolymers. Shashank chaturvedi assistant professor department of pharmaceutics invertis institute of pharmacy invertis university bareilly 11172014 1. Nanoparticles are currently made out of a very wide variety of materials, the most common of the new generation of nanoparticles being ceramics, which are best split into metal oxide ceramics, such as titanium, zinc, aluminum and iron oxides, to name a prominent few, and silicate nanoparticles silicates, or silicon oxides, are also. A variety of preparation techniques have been reported for the synthesis of silver nps.
Degradable polyethylene mimics containing orthoester groups were synthesized by olefin metathesis polymerization for the first time. Skin wound healing is an urgent problem in clinics and military activities. Engineered nanoparticles are intentionally designed and created. Nanoparticles have important properties, including size, shape.
Doxloaded poeus nanoparticles show greatly improved antitumor efficiency. In particular embodiments, polymyxin b, vancomycin, andor other antibiotics are linked to nanoparticles e. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. Because of their size, they have unique material characteristics, and manufactured nanoparticles have practical applications in a variety of areas. These biodegradable polymeric nanoparticles enhance properties such as. They can be classified into different classes based on their properties, shapes or sizes. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pdf polymeric nanoparticles for smallmolecule drugs. Cds or other sulfide nanoparticles can be synthesized using dna. Biosynthesis of silver nanoparticles from orange peel extract and its antibacterial activity against fruit and vegetable pathogens p. Biodegradable polymers for microencapsulation of drugs jae hyung park, mingli ye and kinam park department of pharmaceutics and biomedical engineering, purdue university, 575 stadium mall drive, west lafayette, in 47907, u. The formation of titania nanoparticles was confirmed from xrd and by the dominant ftir peaks at 1, 412 cm. Drug delivery systems, nanoparticles, polyurethanes, cardiovascular diseases.
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